The Cuyabeno Wildlife Reserve  is the second largest reserve of the 45 national parks and protected areas in Ecuador.  It was decreed on 26 July 1979 as part of the creation of the national protected areas system based on the recommendations of the FAO report on the “National Strategy on the Conservation of Outstanding Wild Areas of Ecuador”.

From east to west, the elevation gently slopes from about 300 meters to slightly under 200 m above sea level and has an area of 603,380 ha (1,490,000 acres). The upper watershed being still close to the Andes, the weather seems slightly milder than more eastern parts of the Amazon, with temperatures a bit lower during the day and at night usually cooling to the low twenties (C) or seventies (F).

The Cuyabeno Wildlife Reserve is an important nature reserve in Amazonia with rather unique ecological characteristics. Located at the foothills of the Andes, it is different from any other Amazon protected area in the world.